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Plantar wart

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December 5, 2022

Plantar wart

Verrucae plantaris, usually known as plantar warts, are skin lesions that occur in the plantar area of the foot and are caused by keratinocyte infection by the HPV agent (human papilloma virus).
Mostly asymptomatic, it can affect children, adolescents, and immunocompromised individuals, causing pain and discomfort as well as extensive and visually repulsive lesions.
After its establishment, the HPV is excreted through the desquamated epithelial cells, after which the particles can thus infect other hosts and contaminate sites, and this viral transmissibility is highly facilitated by the therapeutic strategies commonly used, which are based on symptomatological treatments or that intend to avoid contact (which is even less sensible given its ubiquitous presence).
Current treatment strategies have low success rates in eliminating lesions, which are notoriously resistant and recurrent[i], not only because the treatments are mostly not focused on the viral infection[ii] but rather on its visible sign of infection.
Given the high propensity for resistance to plantar wart treatment and the fact that there is no practicality and/or effective prevention method, it is essential that we find new ways to combat this infectious process that eliminate the agent without a deleterious action on the tissues to possible to control the lesions and their transmissibility.

Ozonated Oils – an option?

Ozonated oils are highly effective against this virus, as the trioxolanes, lipoperoxides, and aldehydes present in them are cytotoxic to microorganisms.
Through the oxidation of phospholipids and lipoproteins, ozonated oils damage the viral capsid, disrupt the reproductive cycle, prevent virus-cell contact, and induce peroxidation. Cells with weak enzymatic component cell walls are more vulnerable to viral attacks and simultaneously also more susceptible to oxidation, being subsequently eliminated from the body and replaced by healthy cells.
Upon contact with the skin, the oils produce ozones that promote increased production of interferon, tumour necrosis factor and interleukin-2, thus triggering cascade cell signaling in various immune reactions, impacting invasion and specific immune response.
Data from a publication in April 2021[iii] refers to its usefulness in fighting HPV, while another publication from 2012 had already mentioned its usefulness as well.
Its use on gynaecological HPV warts was successfully reported in June 2021[iv].

[i] Sanclemente G, Gill DK. Human papillomavirus molecular biology and pathogenesis. J Eur Acad Dermatol Venereol. 2002 May;16(3):231-40. doi: 10.1046/j.1473-2165.2002.00419.x. PMID: 12195562.

[ii] Doorbar J, Egawa N, Griffin H, Kranjec C, Murakami I. Human papillomavirus molecular biology and disease association. Rev Med Virol. 2015 Mar;25 Suppl 1(Suppl Suppl 1):2-23. doi: 10.1002/rmv.1822. PMID: 25752814; PMCID: PMC5024016.

[iii] Radzimierska-Kaźmierczak M, Śmigielski K, Sikora M, Nowak A, Plucińska A, Kunicka-Styczyńska A, Czarnecka-Chrebelska KH. Olive Oil with Ozone-Modified Properties and Its Application. Molecules. 2021 May 21;26(11):3074. doi: 10.3390/molecules26113074. PMID: 34063952; PMCID: PMC8196576.

[iv] Scientific rational for the medical application of ozonized oils, an up-date. Ozone Therapy Global Journal; Vol 11, No 1 (2021): Ozone Therapy Global Journal

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