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Ozonated oils and atopic dermatitis

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June 13, 2022

Ozonated oils and atopic dermatitis

Ozone acts as a dermatological agent due to its ability to promote destruction of bacteria, fungi and viruses, -whilst simultaneously activating cellular and humoral immunity, due to its antioxidant effects and defense mechanisms against various pathological conditions.
The therapeutic effects of Ozone Therapy depend upon its concentration, therefore, it is essential to know this factor (PIs).
Ozonated oils are composed of the combination of unsaturated oils and ozone that results in the formation of 1,2,4-trioxolane rings and represent the active form of ozone. This trioxolane ring leads to the production of compounds responsible for the healing processes, even (in fact, we would go as far as to say – especially) in the presence of exudates, that help restore the balance of damaged, ulcerated, or wounded skin of the most diverse etiologies[i].
One of the main advantages of Ozone Therapy with ozonated oils is its patient-friendly use: accessibility in price and easy storage, rapid and visible results, including reduction in itching and edema almost immediately after its application. This enhances patient treatment adherence, without the risk of adverse effects usually associated with cortisone creams.
In addition to being antimicrobial and balancing the skin microbiome, Ozone aso has a moisturizing effect on the skin and protects the skin’s natural barrier, which is especially useful in patients with atopic dermatitis.
Treatment with ozonated oils is a great way to enhance other forms of Ozone Therapy, and can be perfectly combined with these or alternatively complementary to any other types of treatment that are being carried out by the patient.

Table 1 – Clinical applicability of Ozone Therapy and Ozonated Oils

Ozone Preparation Effects Clinical Use Reference
Ozonated water

Ozonated Oils

Pruritus relief
Exudate reduction
Allergic infection
Wound and ulcer healing
Autohemoterapia Antioxidant defenses
Epigenetic modification
Chronic and systemic conditions
(including autoimmune conditions)
Post-herpetic neuralgia

[i] Zeng, J., & Lu, J. (2018). Mechanisms of action involved in ozone-therapy in skin diseases. International Immunopharmacology, 56, 235–241. doi:10.1016/j.intimp.2018.01.040

[ii] G.A. Borges, S.T. Elias, S.S. Da, P.O. Magalhaes, S.B. Macedo, A.P. Ribeiro, et al., In vitro evaluation of wound healing and antimicrobial potential of ozone therapy, J. Craniomaxillofac. Surg. 45 (2017) 364–370.
I. Zanardi, E. Borrelli, G. Valacchi, V. Travagli, V. Bocci, Ozone: a multifaceted molecule with unexpected therapeutic activity, Curr. Med. Chem. 23 (2016) 304–314.
V. Travagli, I. Zanardi, G. Valacchi, V. Bocci, Ozone and ozonated oils in skin diseases: a review, Mediat. Inflamm. 2010 (2010) 610418.
I. Zanardi, S. Burgassi, E. Paccagnini, M. Gentile, V. Bocci, V. Travagli, What is the best strategy for enhancing the effects of topically applied ozonated oils in cutaneous infections? Biomed. Res. Int. 2013 (2013) 702949.
S.A. Pai, S.A. Gagangras, S.S. Kulkarni, A.S. Majumdar, Potential of ozonated sesame oil to augment wound healing in rats, Indian J. Pharm. Sci. 76 (2014) 87–92.

[iii] V. Bocci, I. Zanardia, G. Valacchi, E. Borrelli, V. Travagli, Validity of oxygen-ozone therapy as integrated medication form in chronic inflammatory diseases, Cardiovasc. Hematol. Disord.: Drug Targets 15 (2015) 127–138.
F. Molinari, V. Simonetti, M. Franzini, S. Pandolfi, F. Vaiano, L. Valdenassi, et al., Ozone autohemotherapy induces long-term cerebral metabolic changes in multiple sclerosis patients, Int. J. Immunopathol. Pharmacol. 27 (2014) 379–389.
H. Chen, B. Yu, C. Lu, Q. Lin, The effect of intra-articular injection of different concentrations of ozone on the level of TNF-alpha, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis, Rheumatol. Int. 33 (2013) 1223–1227.
G. Lintas, F. Molinari, V. Simonetti, M. Franzini, W. Liboni, Time and time-frequency analysis of near-infrared signals for the assessment of ozone autohemotherapy long-term effects in multiple sclerosis, Conf. Proc. IEEE Eng. Med. Biol. Soc. 2013 (2013) 6171–6174.
V. Travagli, I. Zanardi, A. Silvietti, V. Bocci, A physicochemical investigation on the effects of ozone on blood, Int. J. Biol. Macromol. 41 (2007) 504–511.

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